PharmaTutor <p><span style="font-family: verdana,geneva,sans-serif;"><span style="font-family: georgia,serif;">The PharmaTutor&nbsp; <strong>(ISSN: 2347 - 7881)</strong> is a monthly published online journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences &amp; Lifesciences.<br></span></span></p> en-US (Dr. Sanjeev Acharya) (Rajesh Vagh) Thu, 01 Aug 2019 11:25:48 +0000 OJS 60 AN EXTENSIVE REVIEW OF PATIENT BEHAVIOR <p class="rtejustify"><span style="font-family: verdana,geneva,sans-serif;">The most frequent causes of death in the United States and globally are chronic diseases, including heart disease, cancer, lung diseases, and diabetes. Behavioral factors, particularly tobacco use, diet and activity patterns, alcohol consumption, sexual behavior, and avoidable injuries are among the most prominent contributors to mortality. Projections of the global burden of disease for the next two decades include increases in noncommunicable diseases, high rates of tobacco-related deaths, and a dramatic rise in deaths from HIV/AIDS. Worldwide, the major causes of death by 2030 are expected to be HIV/AIDS, depressive disorders, and heart disease. At the same time, in many parts of the world, infectious diseases continue to pose grim threats, especially for the very young, the old, and those with compromised immune systems. Malaria, diarrheal diseases, and other infectious diseases, in addition to AIDS, are major health threats to the poorest people around the world. And, like chronic diseases, their trajectory may be influenced by the application of effective health behavior interventions. Substantial suffering, premature mortality, and medical costs can be avoided by positive changes in behavior at multiple levels. Most recently, there has been a renewed focus on public health infrastructure to plan for emergencies, including both human-made and natural disasters. During the past twenty years, there has been a dramatic increase in public, private, and professional interest in preventing disability and death through changes in lifestyle and participation in screening programs. Much of this interest in disease prevention and early detection has been stimulated by the epidemiological transition from infectious to chronic diseases as leading causes of death, the aging of the population, rapidly escalating health care costs, and data linking individual behaviors to increased risk of morbidity and mortality. </span></p> <p class="rtejustify"><span style="font-family: verdana,geneva,sans-serif;"><strong>Purpose of the study:</strong> Discussion and projection of behavior pattern, health seeking behavior and monitoring status in both developed and under-privileged countries. The pharmacists have a vital role to play which is discussed along with comparison.</span></p> <p class="rtejustify"><span style="font-family: verdana,geneva,sans-serif;"><strong>Findings:</strong> Developed or under developed country, patients have a separate behavior pattern which develops and worsen with disease progression mostly. So many factors are behind but one thing clearly understood that the handling of such situation is a provider’s function, a challenge they have to face along with treatment intervention.</span></p> <p class="rtejustify"><span style="font-family: verdana,geneva,sans-serif;"><strong>Research Limitations:</strong> Very few articles found in matters regarding along with a very less interest paid by general people to talk about healthcare matters. It was very difficult to bring out facts of irrational patient behavior, giving it a substantial figure to discuss in this article. However, the major limitation is the article could be a comparison of behaviors of developed and under-privileged countries which requires an enormous exposure and financial support. However, the sole focus was to detail mysterious patient behavior and a greater part is covered.</span></p> <p class="rtejustify"><span style="font-family: verdana,geneva,sans-serif;"><strong>Practical Implication:</strong> The soul of this article was to detail about patient behavior, both in Bangladesh and developed countries. Along with students, researchers and professionals of different background and disciplines, eg. Pharmacists, marketers, doctors, nurses, hospital authorities, public representatives, policy makers and regulatory authorities have to acquire much from this article.</span></p> <p class="rtejustify"><span style="font-family: verdana,geneva,sans-serif;"><strong>Social Implication:</strong> Patient behavior is the Sole of healing system and a scope for pharmacists and other healthcare providers to work with in both developed or under developed countries. The article should contribute an integrated guideline for patient compliance, demand rational behavior and last but not the least a silvery lining to better pharmacists’ dealings with them in near future</span></p> Abdul Kader Mohiuddin ##submission.copyrightStatement## Thu, 01 Aug 2019 11:01:35 +0000 SKIN AGING & MODERN AGE ANTI-AGING STRATEGIES <p><span style="font-family: verdana,geneva,sans-serif;">As the most voluminous organ of the body that is exposed to the outer environment, the skin suffers from both intrinsic and extrinsic aging factors. Skin aging is characterized by features such as wrinkling, loss of elasticity, laxity, and rough-textured appearance. This aging process is accompanied with phenotypic changes in cutaneous cells as well as structural and functional changes in extracellular matrix components such as collagens and elastin. With intrinsic aging, structural changes occur in the skin as a natural consequence of the biological changes over time and produce a certain number of histological, physiological, and biochemical modifications. Intrinsic aging is determined genetically (influence of gender and ethnic group), variable in function of skin site, and also influenced by hormonal changes. Visually it is characterized by fine wrinkles. By comparison, “photoaging” is the term used to describe the changes occurring in the skin, resulting from repetitive exposure to sunlight. The histological, physiological, and biochemical changes in the different layers of the skin are much more drastic. From a mechanical point of view, human skin appears as a layered composite containing the stiff thin cover layer presented by the stratum corneum, below which are the more compliant layers of viable epidermis and dermis and further below the much more compliant adjacent layer of subcutaneous white adipose tissue. Upon exposure to a strain, such a multi-layer system demonstrates structural instabilities in its stiffer layers, which in its simplest form is the wrinkling. These instabilities appear hierarchically when the mechanical strain in the skin exceeds some critical values. Their appearance is mainly dependent on the mismatch in mechanical properties between adjacent skin layers or between the skin and subcutaneous white adipose tissue, on the adhesive strength and thickness ratios between the layers, on their bending and tensile stiffness as well as on the value of the stress existing in single layers. Gradual reduction of elastic fibers in aging significantly reduces the skin’s ability to bend, prompting an up to 4-fold reduction of its stability against wrinkling, thereby explaining the role of these fibers in skin aging. Anti-aging medicine is practiced by physicians, scientists, and researchers dedicated to the belief that the process of physical aging in humans can be slowed, stopped, or even reversed through existing medical and scientific interventions. This specialty of medicine is based on the very early detection and prevention of age-related diseases. Physicians practicing anti-aging medicine seek to enhance the quality of life as well as its length, limiting the period of illness and disability toward the end of one’s life. Anti-aging medicine encompasses lifestyle changes (diet and exercise); hormone replacement therapies, as needed, determined by a physician through blood testing (DHEA, melatonin, thyroid, human growth hormone, estrogen, testosterone); antioxidants and vitamin supplements; and testing protocols that can measure not only hormone levels and blood chemistry but every metabolic factor right down to the cellular level.</span></p> Abdul Kader Mohiuddin ##submission.copyrightStatement## Thu, 01 Aug 2019 11:10:10 +0000 Hypertension and Pregnancy : an important issue <p><span style="font-family: verdana,geneva,sans-serif;">Hypertensive disorders of pregnancy are the common medical disorders in pregnancy. It has effects both on expectant mother and foetus. The impact due to hypertensive disorders in pregnancy on maternal and neonatal mortality and morbidity is very high in India and other developing countries. The incidence of pregnancy induced hypertension in India is about 7-10% of all antenatal admission. Severe forms of hypertensive disorders of pregnancy like eclampsia is a major cause of maternal mortality. Hypertensive disorders in pregnancy complicate 1 in 10 pregnancies, often associated with maternal and neonatal mortality and morbidity. Pregnancy induced hypertension is one of the common medical disorders of pregnancy. It complicates 6 to 8% of pregnancies and is the third common cause for maternal mortality and morbidity next to haemorrhage and infections. 18% of maternal deaths are due to pregnancy related hypertension complications. It affects both mother and foetus. Hypertension during pregnancy predisposes to complications like eclampsia, abruptio placentae, disseminated intravascular coagulation, pulmonary oedema, blindness, cerebrovascular haemorrhages, HELLP syndrome, foetus growth restriction and foetal demise. Controlling hypertension in pregnancy prevents complications both in mother and foetus. There are various theories for the aetiology of pregnancy induced hypertension. The common pathophysiological changes seen are imbalance between vasoconstrictor thromboxane and vasodilator prostacyclin resulting in generalised vasospasm. This leads to endothelial damage resulting in release of vasoactive substances. This causes decreased intravascular volume and increased extravascular volume. The effects of this are placental insufficiency resulting in complications. Controlling hypertension in pregnancy using antihypertensive drugs brings down these complications. In this review, we will briefly discuss about Pregnancy induced Hypertension, its pathophysiology, diagnosis and its management.</span></p> Mudasir Maqbool, Misba Khan ##submission.copyrightStatement## Thu, 01 Aug 2019 11:12:35 +0000 Review article on: Synthesis and Biological activities of Allyl Sulfides <p><span style="font-family: verdana,geneva,sans-serif;">The current review frameworks different approaches of synthesis and various biological activities of allyl sulfides. The food-based natural products (allyl sulfides) are major organo-sulfur constituent of garlic had been studied extensively due to their moderate toxicity accompanied by number of biological applications such as anti-cancer, anti-microbial, antibiotic, antimutagenic and detoxification etc. The broad-spectrum application of allyl sulfides inspires us to do advance research on it.</span></p> Pomila Sharma, Anjali Sidhu ##submission.copyrightStatement## Thu, 01 Aug 2019 11:24:00 +0000