Preparation and Characterization of Ethyl Cellulose based Salbutamol Sulphate and Theophylline Combination Microsphere

  • Chandan Nayak Gayatri Institute of Science and Technology
  • Priyanka Padhi Gayatri Institute of Science and Technology
Keywords: Microspheres, In vitro drug release, RPM, UV, DSC

Abstract

The study is concerned with the development of Ethyl Cellulose microspheres by the o/w emulsification and solvent evaporation method in the presence of tween 80 as an emulsifying agent. The influence of process parameters such as solvent mixture, composition, concentration of the emulsifying agent and speed of stirring has been examined. The microspheres have been analysed for their size, drug loading capacity and drug release study. Spherical and smooth surfaced microspheres with desired encapsulation efficiencies were obtained. Slow drug release from microspheres observed up to6- 8 h. An optimization procedure was employed to investigate and identify the key parameters affecting the properties of the microspheres.

Author Biographies

Chandan Nayak, Gayatri Institute of Science and Technology

Gayatri Institute of Science and Technology,
Gunupur, Rayagada,
Odisha, India

Priyanka Padhi, Gayatri Institute of Science and Technology

Gayatri Institute of Science and Technology,
Gunupur, Rayagada,
Odisha, India

References

1. Ainley Wade & Paul J. Weller, Handbook of Pharmaceutical Excipients, 2nd edition, The Pharmaceutical Press, London, 1994; pp 186-190.
2. Das MK and Rao KR. Evaluation of zidovudine encapsulated ethyl cellulose microspheres prepared by water in oil in oil (w/o/o) double emulsion solvent diffusion technique. Acta Pol Pharm., 63(2); 141-148.
3. Gibaud S, Bonneville A, Astier A. Preparation of 3,4- diaminopyridine microparticles by solvent-evaporation methods. Int J Pharm., 242:197-201.
4. Hitesh K, Koshy MK, Shubhini AS. Gastroretentive Ethyl Cellulose Floating Microspheres containing Ranitidine Hydrochloride. Int. J. Drug Dev. & Res., 4(2); 315321.5. Kilicarslan M, Baykara T. The effect of the drug/polymer ratio on the properties of the verapamil HCl loaded microspheres. Int J Pharm., 252; 99-109.
6. Naveen C, Kirankumar Y, Rashmi V. Preparation and Evaluation of Ethyl Cellulose Microspheres Containing Diclofenac Sodium by Novel W/O/O Emulsion Method. J. Pharm. Sci. & Res., 2(12); 884-888.
7. Remington’s, The Science and Practice of Pharmacy, 21st edition, Volume–I, Lippincott, Williams and Wilkins, Philadelphia, 2006; pp 316.
8. Saravanan M, Dhanaraju D, Sridhar SK, Ramachandran S, Kishore GS, Anand P, Bhaskar K, Srinivasarao G. Preparation, Characterization and In vitro release kinetics of ibuprofen polystyrene microspheres. Ind.J.Pharm.Sci, 66 (3); 287-292
Published
2018-04-01
How to Cite
[1]
Nayak, C. and Padhi, P. 2018. Preparation and Characterization of Ethyl Cellulose based Salbutamol Sulphate and Theophylline Combination Microsphere. PharmaTutor. 6, 4 (Apr. 2018), 51-69. DOI:https://doi.org/10.29161/PT.v6.i4.2018.51.
Section
Articles