Microbial Biofilms: Pathogenicity and Treatment strategies

  • Pratyush Kumar Das Siksha ‘O’ Anusandhan University
  • Smrutipragnya Samal Siksha ‘O’ Anusandhan University
Keywords: Biofilm, Extracellular polymeric substances, antibiotics, microorganisms, Quorum sensing, Resistance

Abstract

Microbial biofilms are complex structures wherein the planktonic cells change their growth mode to the sessile form. This kind of growth is assisted by the formation of a matrix of extracellular polymeric substances (EPS) which encapsulates the bacterial cells within it and thus, provides an additional protection. These biofilms are highly resistant to high concentration of antibiotics and poses a great threat towards public health. These biofilms are even beyond the access of a normal human immune system and are involved in infections of teeth, lungs and many other diseases. There lies an immediate need to replace the extensive use of antibiotics with new emerging strategies. The review intends to provide an insight on the various perspectives of microbial biofilms including their formation, composition, mechanism of communication (Quorum sensing) and pathogenicity. Recent emerging strategies have also been discussed that can be considered for successful eradication or inhibition of biofilms and related infections.

Author Biographies

Pratyush Kumar Das, Siksha ‘O’ Anusandhan University

Centre for Biotechnology,
Siksha ‘O’ Anusandhan University,
Bhubaneswar, Odisha, India.

Smrutipragnya Samal, Siksha ‘O’ Anusandhan University

Centre for Biotechnology,
Siksha ‘O’ Anusandhan University,
Bhubaneswar, Odisha, India.

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Published
2018-01-01
How to Cite
[1]
Das, P.K. and Samal, S. 2018. Microbial Biofilms: Pathogenicity and Treatment strategies. PharmaTutor. 6, 1 (Jan. 2018), 16-22. DOI:https://doi.org/10.29161/PT.v6.i1.2018.16.
Section
Articles

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