Dendrimers: A novel carrier for drug delivery system

  • Noopur Pandey Global Institute of Pharmaceutical Education and Research
  • Kamal Mahara Global Institute of Pharmaceutical Education and Research
Keywords: Dendrimers, Drug Delivery, nanotechnology

Abstract

Dendrimers are macromolecules having highly branched, 3 D structure, nano scale architecture with monodispersity and high functionality. These properties make it attractive candidates as unique and optimum drug carriers for controlled release or targeted delivery. Dendrimer is a smart polymer and as a result of their behavior dendrimers are suitable for a wide range of biomedical and industrial applications and in medical applications such as drug delivery, tumor therapy, diagnostics etc. The field of dendrimers has recently emerged as the most commercially viable technology of this century because of its wide ranging potential applications in many fields such as: healthcare, electronics, photonics, biotechnology, pharmaceuticals, drug delivery, catalysis and nanotechnologies. The review aims mainly on the introduction, objectives, properties, synthesis and applications, in future aspects of dendrimers. Dendrimers help in achieving increased bioavailability, sustained, controlled and targeted release of drug.

Author Biographies

Noopur Pandey, Global Institute of Pharmaceutical Education and Research

Department of Pharmaceutics
Global Institute of Pharmaceutical Education and Research,
Kashipur, Dehradun,
Uttaranchal, India

Kamal Mahara, Global Institute of Pharmaceutical Education and Research

Department of Pharmaceutics
Global Institute of Pharmaceutical Education and Research,
Kashipur, Dehradun,
Uttaranchal, India

References

1. Bai S, Thomas C, Ahsan F. Dendrimers as a carrier for pulmonary delivery of enoxaparin, a low molecular weight heparin. J Pharm Sci., 2007; 96(8): 2090-106.
2. Singh U, Dar M, Hashmi A. Dendrimers: synthetic strategies, properties and applications. Oriental J of Chem., 2014; 30(3): 911-922.
3. Barbara K and Maria B. Dendrimers: properties and applications. Acta Bio chimia Polonica, 2001; 48 (1): 199-208.
4. Tripathi S and Das MK. Dendrimers and their applications as novel drug delivery carriers. J of applied Pharm. Sci., 2013; 3(9): 142-149.
5. Bharali DJ, Khalil M, Gurbuz M, Simone TM, Mousa SA. Nanoparticles and cancer therapy: A concise review with emphasis on dendrimers. Int. J Nano medicines, 2009; 4: 1 -7.
6. Bulgier E, Werner W, Vogtle F. Cascade and Nonskid chain like Synthesis of Molecular Cavity Topologies. Synthesis, 1978; 2: 155 -158.
7. Chai M, Niu Y, Youngs WJ, Rinaldi PL. Structure and conformation of DAB dendrimers in solution via multidimensional NMR techniques. J. Am. Chem. Soc, 2001; 123: 4670 –4678.
8. Chauhan AS, Jain NK. Dendrimer mediated transdermal delivery; enhanced bioavailability of Indomethacin. J. Controlled Release, 2003; 96: 537-540.
9. Cheng Y. Dendrimers as Drug carrier: applications in different routes of drug administration. J. Pharm. Sci., 2008; 97: 33 -36.
10. Gupta U, Agashe H, Jain NK. Polypropylene imine dendrimer mediated solubility enhancement: effect of Ph and functional groups of hydrophobes. J Pharm Sci, 2007; 10(3): 358-67.
11. Hawker C and Frechet JM. A new convergent approach to monodisperse dendritic molecule. J. Chem. Soc. Chem., 1990; 15: 1010-1012.
12. Kolhe P, Misra E, Kannan RM, Kannan S, Lai ML. Drug complexation, in vitro release and cellular entry of dendrimers and hyper branched polymers. Int. J. Pharm., 2003; 259: 143-160.
13. Liu M, Kono K, Frechet JM. Water soluble dendrimer poly (ethylene glycol) star like conjugates as potential drug carrier. Journal of Polymer Sciences, Part A, Polymer Chemistry, 1999; 37(17): 3492-3503.
14. Malik A, Chaudhury S, Garg G, Tomar A. Dendrimers: A tool for Drug Delivery. Advances in Biological Research, 2012; 6(4): 165-169.
15. Trivedi V, Patel U, Bhimani B, Patel G. Dendrimer: Polymer of 21st century. Int. J. of Pharm. Res. and BioSci, 2012; 1(2): 1-21.
16. Mohammad N and Antony D. Crossing cellular barriers using dendrimer nanotechnologies. Current Opinion in Pharmacology, 2006; 6: 522–527.
17. Tomalia DA. Birth of a new macromolecular architecture: Dendrimers as quantized building blocks for Nanoscale synthetic organic chemistry. Aldrichimica Acta, 2004; 37 (2): 39-57.
18. Neerman MF, Zhang W, Parrish AR, Simanek EE. In vitro and in vivo evaluation of a melamine dendrimer as a vehicle for drug delivery. Int. J. Pharm., 2004; 281: 129–132.
19. Rajesh babu V, Mallikarjun V, Nikhat SR, Srikanth G. Dendrimers: A new carrier system for Drug Delivery. International Journal of Pharmaceutical and Applied Sciences, 2010; 1(1): 1-10.
20. Roberts JC, Bhalgat MK, Zera RT. Preliminary biological evaluation of polyamidoamine (PAMAM) Starburst (TM) dendrimers. J Biomed Mater Res, 1996; 30: 53–65.
21. Saktivel T, Toth I, Florence AT. Synthesis and physicochemical properties of lipophillic polyamide dendrimers. Pharm. res., 1998; 15: 776 -782.
22. Sonke S and Tomalia DA. Dendrimers in biomedical applications reflections on the Field. Advanced Drug Delivery Reviews, 2005; 57: 2106 –2129.
23. Tomalia DA, Baker H, Dewald J, Hall M, Kallos G, Martin S, Roeck J, Ryder J ,Smith P. A New Class of Polymers: Starburst-Dendritic Macromolecules. Polym. J., 1985; 17(1): 117-132.
24. Wang DJ and Imae T. Fluorescence emission from Dendrimer and its pH dependence. J. Am. Chem. Soc., 2004; 126 (41): 13204-13205.
25. Yang H and Kao WJ. Dendrimers for pharmaceutical and biomedical application. Journal of Biomaterial Sciences, polymer edition, 2006, 17: 3-19.
Published
2017-10-01
How to Cite
[1]
Pandey, N. and Mahara, K. 2017. Dendrimers: A novel carrier for drug delivery system. PharmaTutor. 5, 10 (Oct. 2017), 48-54.
Section
Articles