Formulation development and in vitro evaluation of mouth dissolving tablets of Pioglitazone Hydrochloride

  • Kambham Venkateswarlu Jawaharlal Nehru Technological University Anantapur,
  • Jami Komala Preethi Jawaharlal Nehru Technological University Anantapur
Keywords: Mouth dissolving tablets, Pioglitazone, Direct compression, Wet granulation, dissolution enhancement

Abstract

The present investigation was focused on formulation and in vitro evaluation of mouth dissolving tablets (MDTs) of Pioglitazone Hydrochloride (PGTZN) thereby enhancing the dissolution rate. MDTs were prepared by wet granulation and direct compression methods using Croscarmellose sodium, Crospovidone and Sodium starch glycolate as superdisintegrants. Powder blends were evaluated for flowability and all the powder blends showed acceptable flowability. The prepared tablets were evaluated for post compression parameters like hardness, friability, wetting time and showed acceptable results. Formulations F8 and F15 showed disintegration time of 23 and 22 sec respectively. Dissolution was performed in pH 1.2 HCl buffer and formulations F15 showed maximum drug release within 30 min. drug release from F15 was more than that of the marketed drug. Hence, it could be concluded that formulation F15 showed good drug release than marketed drug and there is a lot of scope for future in vivo studies.

Author Biographies

Kambham Venkateswarlu, Jawaharlal Nehru Technological University Anantapur,

Department of Pharmaceutics,  JNTUA-Oil Technological and Pharmaceutical Research Institute, 
Jawaharlal Nehru Technological University Anantapur,
Ananthapuramu, Andhra Pradesh, India.

Jami Komala Preethi, Jawaharlal Nehru Technological University Anantapur

Department of Pharmaceutics,  JNTUA-Oil Technological and Pharmaceutical Research Institute, 
Jawaharlal Nehru Technological University Anantapur,
Ananthapuramu, Andhra Pradesh, India.

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Published
2016-12-01
How to Cite
[1]
Venkateswarlu, K. and Preethi, J.K. 2016. Formulation development and in vitro evaluation of mouth dissolving tablets of Pioglitazone Hydrochloride. PharmaTutor. 4, 12 (Dec. 2016), 37-42.