Antiepileptic activity of Murraya Koenigii Leaf Extracts

  • AM Bhandari A.R.College of Pharmacy & G.H.Patel Institute of Pharmacy
  • JA Sathwara A.R.College of Pharmacy & G.H.Patel Institute of Pharmacy
Keywords: Murraya koenigii, Antiepileptic activity, Seizures, Pentylenetetrazole

Abstract

The aim of the present study was to investigate antiepileptic effect of the aqueous extract of the leaves of Murraya koenigii L. Spreng (AEMK) on electrically and chemically induced seizures. The aqueous extract of the leaves of M. koenigii (200 and 300 mg/kg) were studied for its antiepileptic effect on maximal electroshock induced seizures and pentylenetetrazole induced seizures in mice. AEMK (200 and 300 mg/kg) significantly reduced the duration of seizures induced by maximal electroshock (MES) as well as protected animals from pentylenetetrazole induced tonic seizures. The results suggest that the aqueous extract of the leaves of M. koenigii may produce its antiepileptic effects via non-specific mechanisms since it reduced the duration of seizures produced by maximal electroshock as well as delayed the latency of seizures produced by pentylenetetrazole.

Author Biographies

AM Bhandari, A.R.College of Pharmacy & G.H.Patel Institute of Pharmacy

Department of Clinical Pharmacy,
A.R.College of Pharmacy & G.H.Patel Institute of Pharmacy, V.V. Nagar,
Anand, Gujarat, India

JA Sathwara, A.R.College of Pharmacy & G.H.Patel Institute of Pharmacy

Department of Pharmacology,
A.R.College of Pharmacy & G.H.Patel Institute of Pharmacy, V.V. Nagar,
Anand, Gujarat, India

Published
2016-11-01
How to Cite
[1]
Bhandari, A. and Sathwara, J. 2016. Antiepileptic activity of Murraya Koenigii Leaf Extracts. PharmaTutor. 4, 11 (Nov. 2016), 41-44.