Formulation and evaluation of Oro Disintigrating tablets of Resperidone by using Sublimation and Solid Dispersion Technique

  • V. T. Iswariya M.R.R. College of Pharmacy
  • A. Hariomprakash Rao M.R.R. College of Pharmacy
  • K Sri Jahnavi M.R.R. College of Pharmacy
  • A. Sravanthi M.R.R. College of Pharmacy
  • P. Deepa M.R.R. College of Pharmacy
  • K. Samatha M.R.R. College of Pharmacy
Keywords: Resperidone, Solid dispersion, Sublimation, dissolution

Abstract

The technique of Solid dispersion and sublimation techniques are a promising method towards enhancing the dissolution of poorly soluble drugs. The main objective of Resperidone mouth dissolving tablets is to enhance the solubility. Several formulations of solid dispersion and sublimating tablets were prepared by using different ratio of drug sublimating agent (Camphor) and carriers (PEG 4000, Polaxomer, Mannitol). The prepared Solid dispersion and sublimating tablets were evaluated for their flow properties such as bulk density, tapped density, angle of repose, Carr’s index and Hausner’s ratio. The interaction between drug and excipients were studied by FTIR. In vitro dissolution profiles of the solid dispersion and sublimation formulations were studied and compared between sublimation and solid dispersion formulation. Among all formulations SD2 formulation was shown maximum drug release in less time.

Author Biographies

V. T. Iswariya, M.R.R. College of Pharmacy

M.R.R. College of Pharmacy,
Nadergul, Andhra Pradesh, India

A. Hariomprakash Rao, M.R.R. College of Pharmacy

M.R.R. College of Pharmacy,
Nadergul, Andhra Pradesh, India

K Sri Jahnavi, M.R.R. College of Pharmacy

M.R.R. College of Pharmacy,
Nadergul, Andhra Pradesh, India

A. Sravanthi, M.R.R. College of Pharmacy

M.R.R. College of Pharmacy,
Nadergul, Andhra Pradesh, India

P. Deepa, M.R.R. College of Pharmacy

M.R.R. College of Pharmacy,
Nadergul, Andhra Pradesh, India

K. Samatha, M.R.R. College of Pharmacy

M.R.R. College of Pharmacy,
Nadergul, Andhra Pradesh, India

Published
2016-09-01
How to Cite
[1]
Iswariya, V.T., Rao, A.H., Jahnavi, K.S., Sravanthi, A., Deepa, P. and Samatha, K. 2016. Formulation and evaluation of Oro Disintigrating tablets of Resperidone by using Sublimation and Solid Dispersion Technique. PharmaTutor. 4, 9 (Sep. 2016), 46-54.