Development and In-Vitro Drug Release Profile of Sustained release Floating Granules of Cinnarizine

  • Aman Mittal Smt. Tarawati Institute of Biomedical & Allied Science
Keywords: Floating Drug Delivery, Buoyant, Antagonist, Gastro Retentive, Multiparticulate System

Abstract

Floating drug delivery systems (FDDS) are the drug delivery systems having a bulk density lower than the gastric content and they remain buoyant in the stomach for a prolonged period of time, with the potential for continuous release of drug. Cinnarizine, a H1-receptor antagonist, used for the treatment for vestibular vertigo disorders and motion sickness was selected as the drug aspirant and Gelucire 43/01 was selected as a lipid carrier in different ratio (1:0.5, 1:1, 1:1.5) along with drug to be formulated as gastro retentive multiparticulate system. The formulation F1 to F9 were prepared and formulation F4 to F9 were evaluated for in-vitro drug release and formulation F5 was selected as optimized formulation that exhibited good floating ability and zero order drug release (93.56 %) at the end of 8 hrs. The in-vitro drug release study of the aged sample show phase conversion of Gelucire. The phase conversion also caused increase in drug release. In conclusion, hydrophobic lipid, Gelucire 43/01 can be considered as an effective carrier for design of a multiple unit floating drug delivery system of cinnarizine.

Author Biography

Aman Mittal, Smt. Tarawati Institute of Biomedical & Allied Science

Smt. Tarawati Institute of Biomedical & Allied Science, Roorkee,
HP, India

Published
2016-08-01
How to Cite
[1]
Mittal, A. 2016. Development and In-Vitro Drug Release Profile of Sustained release Floating Granules of Cinnarizine. PharmaTutor. 4, 8 (Aug. 2016), 27-35.
Section
Articles