Formulation and Evaluation of Metformin Hydrochloride buccal patch

  • S. Z. Chemate Padmashri Dr. Vithhalrao Vikhe Patil Foundation’s College of Pharmacy
  • Vaishali N. Garje Padmashri Dr. Vithhalrao Vikhe Patil Foundation’s College of Pharmacy
  • Shubhada A. Gayake Padmashri Dr. Vithhalrao Vikhe Patil Foundation’s College of Pharmacy
Keywords: Metformin Hydrochloride, buccal patch, antihyperglycemic agent

Abstract

The aim of present investigation was to design and evaluate, mucoadhesive buccal patch of Metformin hydrochloride, a BCS class II drug, to provide unidirectional sustained drug delivery to the buccal mucosa that has potential to enhance the bioavailability. The patches were prepared using HPMC K4M as a polymer, polyethylene glycol 400 as a plasticizer, by solvent casting technique. The patches, which were prepared by the solvent casting method, were smooth and elegant in appearance; were uniform in thickness, weight and drug content; showed no visible cracks; and showed good folding endurance. The amount of polymer, which significantly influenced characteristics like swelling index, mucoadhesive strength, diffusion study.

Author Biographies

S. Z. Chemate, Padmashri Dr. Vithhalrao Vikhe Patil Foundation’s College of Pharmacy

Department of Pharmaceutics,
Padmashri Dr. Vithhalrao Vikhe Patil Foundation’s College of Pharmacy,
Ahmednagar, Maharashtra, India

Vaishali N. Garje, Padmashri Dr. Vithhalrao Vikhe Patil Foundation’s College of Pharmacy

Department of Pharmaceutics,
Padmashri Dr. Vithhalrao Vikhe Patil Foundation’s College of Pharmacy,
Ahmednagar, Maharashtra, India

Shubhada A. Gayake, Padmashri Dr. Vithhalrao Vikhe Patil Foundation’s College of Pharmacy

Department of Pharmaceutics,
Padmashri Dr. Vithhalrao Vikhe Patil Foundation’s College of Pharmacy,
Ahmednagar, Maharashtra, India

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Published
2016-07-01
How to Cite
[1]
Chemate, S., Garje, V. and Gayake, S. 2016. Formulation and Evaluation of Metformin Hydrochloride buccal patch. PharmaTutor. 4, 7 (Jul. 2016), 52-58.
Section
Articles