Evaluation of effects of Commiphora Wightii in Dehydroepiandrosterone (DHEA) induced Polycystic Ovary Syndrome (PCOS) in Rats
Background: Hyperandrogenism and insulin resistance are the main manifestations of polycystic ovary syndrome (PCOS), which appears to be caused by exposure to androgenized models have developed and investigated to study the etiology of polycystic ovary syndrome.
Objective: To evaluate the modulatory effects of Commiphora wightii (C.wightii) resins in response to hyperandrogenism in polycystic ovary syndrome.
Method: The animals were divided 18 adult (5-6 months old) wistar rats in to 4 groups the PCOS model was induced by daily administration of dehydroepiandrosterone (DHEA) 6mg/Kg in sesame oil p.o., up to 15 days and the rescue groups were take daily with metformin and C.wightii resin ethanolic extract 100mg/ kg in addition to DHEA. Serum glucose levels measured and steroid hormone levels were measured by fully automated bidirectionally interfaced chemi luminescent immunoassay. Samples were stained with hematoxylin and eosin for histological morphology.
Results: The obtained results related to DHEA induced PCOS a significant (P<0.05) increase in hormone profile (estradiol, testosterone, progesterone, luteinizing hormone, follicle stimulated hormone) in PCOS rats in adult rats than the rescue groups. Furthermore glucose levels significantly (<0.05) elevated in PCOS rats compared with the other groups. The test treated ovaries had lower number of follicles compared to DHEA control group and similar to that of the control group than the standard.
Conclusion: Commiphora wightii resin has a potential role in reducing DHEA induced PCOS by reducing the morphological abnormalities of the ovarian follicles and normal hormone levels in adult rats.
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