Bio-Markers and Bio-Sensors: Unravelling the Major Mechanistic Interventions in Cancer Prognosis

  • Rajesh Tiwari Central University of Punjab
Keywords: Molecular Signature, Biomarkers, Cancer, Biosensors, Electrochemical detection, Transducer, Point of care testing

Abstract

Biosensors are a tool that combines the biochemical element with a transducer that generates an indication for the identification of disease. Numbers of biosensors are used in different medical application. Biomarker and Biosensors play an important role for early stage exposure of cancer. It is a cost-effective, increased assay speed, resiliency, the ability for multi-target analysis method. Genomic and proteomic molecular tools are also used for the exposure of tumors. These methods produce a molecular mark that provides a new opening for utilizing biosensors and biomarkers. As with many disease conditions, it is not easy to find exact and responsive markers that are associated with only one marker. Different numbers of molecular signatures are used for the diagnosis of cancer, such as proteins, peptides, overexpression gene and gene mutation. This review provides a general idea of the biosensors and biomarkers technology that is currently developed and researched for cancer markers and diagnosis.

Author Biography

Rajesh Tiwari, Central University of Punjab

Pharmaceutical Science and Natural Products
Central University of Punjab,
Bathinda, India

References

1. Joshi G, Singh PK, Negi A, Rana A, Singh S, Kumar R. Growth factors mediated cell signalling in prostate cancer progression: Implications in discovery of anti-prostate cancer agents. Chemico-biological interactions. 2015;240:120-33.
2. Hanahan D, Weinberg RA. The hallmarks of cancer. cell. 2000;100(1):57-70.
3. Rasooly A, Jacobson J. Development of biosensors for cancer clinical testing. Biosensors and Bioelectronics. 2006;21(10):1851-8.
4. Soper SA, Brown K, Ellington A, Frazier B, Garcia-Manero G, Gau V, et al. Point-of-care biosensor systems for cancer diagnostics/prognostics. Biosensors and Bioelectronics. 2006;21(10):1932-42.
5. Wang J. Electrochemical biosensors: towards point-of-care cancer diagnostics. Biosensors and Bioelectronics. 2006;21(10):1887-92.
6. Tothill IE, editor Biosensors for cancer markers diagnosis. Seminars in cell & developmental biology; 2009: Elsevier.
7. Nilsson J, Skog J, Nordstrand A, Baranov V, Mincheva-Nilsson L, Breakefield X, et al. Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer. British journal of cancer. 2009;100(10):1603-7.
8. Geisler C, Gaisa NT, Pfister D, Fuessel S, Kristiansen G, Braunschweig T, et al. Identification and validation of potential new biomarkers for prostate cancer diagnosis and prognosis using 2D-DIGE and MS. BioMed research international. 2015;2015.
9. Arya SK, Bhansali S. Lung cancer and its early detection using biomarker-based biosensors. Chemical reviews. 2011;111(11):6783-809.
10. Pingarrón JM, Yanez-Sedeno P, González-Cortés A. Gold nanoparticle-based electrochemical biosensors. Electrochimica Acta. 2008;53(19):5848-66.
11. Zhang S-Y, Lin M, Zhang H-B. Diagnostic value of carcinoembryonic antigen and carcinoma antigen 19-9 for colorectal carcinoma. Int J Clin Exp Pathol. 2015;8(8):9404-9.
12. Mascini M, Tombelli S. Biosensors for biomarkers in medical diagnostics. Biomarkers. 2008;13(7-8):637-57.
13. Scott JM, Jones LW, Hornsby WE, Koelwyn GJ, Khouri MG, Joy AA, et al. Cancer therapy-induced autonomic dysfunction in early breast cancer: implications for aerobic exercise training. International journal of cardiology. 2014;171(2):e50.
14. Gouvea C. Biosensors for health applications: INTECH Open Access Publisher; 2011.
15. Wu NN, editor Biosensors for Health Care and Food Safety Applications. 228th ECS Meeting (October 11-15, 2015); 2015: Ecs.
16. Ermilov SA, Khamapirad T, Conjusteau A, Leonard MH, Lacewell R, Mehta K, et al. Laser optoacoustic imaging system for detection of breast cancer. Journal of biomedical optics. 2009;14(2):024007--14.
17. Wang J, Nielsen PE, Jiang M, Cai X, Fernandes JR, Grant DH, et al. Mismatch-sensitive hybridization detection by peptide nucleic acids immobilized on a quartz crystal microbalance. Analytical chemistry. 1997;69(24):5200-2.
18. Zhang H, Kim ES. Micromachined acoustic resonant mass sensor. Microelectromechanical Systems, Journal of. 2005;14(4):699-706.
Published
2015-12-01
How to Cite
[1]
Tiwari, R. 2015. Bio-Markers and Bio-Sensors: Unravelling the Major Mechanistic Interventions in Cancer Prognosis. PharmaTutor. 3, 12 (Dec. 2015), 17-22.